Cbs gene mutation symptoms reddit. Fast CBS Enzyme = excess taurine and ammonia.

Cbs gene mutation symptoms reddit CBS also. Currently taking: Morning: 800mg sam-E Evening: 800mg sam-E, b6 zinc 50mg w/ copper 2mg, vitamin D, 400mg magnesium, 600mg… This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Another video regarding the CBS gene mutation in the transulfuration pathway. Your detox profile is also important so add that to your post. rs5742905=CBS T833C. DNA analysis can also be performed, especially in high-risk populations, for newborn screening and families with known CBS mutations. You want to use folinic acid and the adeno and hydroxy forms of B12. comments sorted by Best Top New Controversial Q&A Add a Comment Oct 8, 2024 · Higher levels of vitamin B6 mean higher activity of the CBS enzyme, lower homocysteine, higher glutathione, and improved symptoms in the realms of brain function, energy, mood, detoxification, and more. I have the homozygous CBS C699T mutation and single MTHFR 677T mutation. COMT You would be super sensitive to being anxious and overstimulated. This can result in attention type symptoms. I have a CBS gene mutation that can produce excess sulfur A microbiome test has showed that I have excess sulfur bacteria. This gene mutation can present as sulfur intolerance and has been correlated with sibo of all types, including H2S and many other chronic health conditions. You need to address CBS first. Members Online Very recent paper linking MTHFR 667TT to potentially worse Erectile Dysfunction. I don't think I react to them but it's hard to say with what I have going on. e. Lower than optimal homocysteine is not better. Is Sulforaphane contraindicated for MTHFR / CBS? I’m trying Sulforaphane as I need detoxification help, but I’m afraid that I could be shooting my self in the foot due to the sulfur component. Recall however that it isnt one CBS gene/enzyme code in humans but many, and they are a mixture of fast and slow CBS polymorphisms. Please be cautious about following anyone's supplement recommendations. Jul 24, 2021 · The CBS gene – cystathionine beta-synthase – codes for the CBS enzyme that acts within the transsulfuration pathway. co/sgkTb6V. I hope this helps. Within a few days of starting I was able to expand my diet. According to Dr. In my case, I have started taking folinic acid with Methyl B12 just today. 1. Can someone advise me on how to deal with OCD-like symptoms (Neat freak, but doesnt click the light switch 7 times), Fatigue, And more. Members Online Comfortable-Bid-7809 CBS gene mutation which is a non MTHFR gene mutation for sure. Members Online Methyl B12, Methyl Folate, and P5P have done absolutely nothing for me. I had endless unnatural energy, maybe a little short tempered and stronger emotions in general, but I couldn't feel it, but now 300mcg methylcobalamin and just 300mcg methylfolate a few days ago had me ready to freak out. " Based on a quick glance, doesn't appear that you have the CBS upregulations or slow COMT. As a result, homocysteine and other potentially toxic compounds build up in the blood, and homocysteine is excreted in urine. Members Online What is the difference between tmg vs methionine and sam e? Choline is contra indicated or not recommended or would make you feel pretty crappy if you have the CBS gene mutation. Some people, including doctors, can go overboard with recommending supplements. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro… Ran my DNA results through genetic genie and have homozygous for both mutations plus a bunch of heterozygous results been doing some research and everything people recommend including in a diet for mthfr C677T (dark leafy greens, fish, nuts, eggs etc ) are meant to be avoided for the CBS mutation C699T due sulphur intolerance. I was able to determine that I should be supplementing, B2 (Riboflavin-5'-phosphate) for my MAO A R297R Mutation, Vitamin D for my VDR Taq mutation (Should help support my COMT mutations that appear to be manageable through supplementing Vitamin D for my VDR taq issues) And for my MTHFR Mutations, Methylfolate has been recommended, however you I'm heterozygous for CBS C699T and A360A; I got the results back a few days ago. The CBS enzyme reduces homocysteine to an intermediate (cysteine) that eventually can become glutathione, an important antioxidant in the body. With that being said, your CBS gene is also relevant as it regulates Homocysteine. Carnivore initially helped my bloating, but my digestion took a hit and I think it led to my H2S SIBO. It makes me short of breath. The genes saying to avoid are ACHY rs819146 TT, COMT rs4680 (Val158Met) AA, and I've got a few CBS mutations that say to avoid. There are other reasons as well, but yes either a sudden increase or decrease in CBS can affect these reactions. Not a dangerous thing, just not comfortable. Please join and read the information in the files. I’m new to my genes, homozygous for PEMT - AA, the bad one, also C677T MTHFR homozygous. CBS A13637G T TT. Does anyone here know they have a CBS upregulation gene causing excess sulfur and ammonia? Or do you suffer symptoms inc GI from high sulfur foods? Eggy Burps and Wind? Also ammonia smelling urine and sweat. The following lists some resources to read regarding CBS. I believe supplements should be treated carefully and the wrong types and dosages can cause harm. Initial studies showed that the risk ‘T’ allele was associated with increased CBS activity 7, although later studies showed no risk, or even the opposite effect 8,9. B12 can be high because you might have one or more of the FUT2 gene variants. Thanks! I've come across discussion about CBS in the MCAS group and when looking into sulfur sensitivity. I'm curious about adding in a methyl B vitamin. So, I have really dug deep into this (also have Gilbert's, not sure it is related). I came across an old post from someone on a similar site criticizing the "lack of science" about Dr Methyls and methyl donors will result in dopamine peaks and drops which can bring on symptoms. Look for the post by Previous_Length9924 and read my comments about CBS. I was fine the first day… This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. CBS does not trump all others unless you have CBS symptoms, which may include severe brain fog and smelling and or tasting sulfur and or ammonia when eating too much sulfur and sulfites. This subreddit is for people with MTHFR mutations and those who are interested in discussing the science and health implications of MTHFR mutations. So yeah, my B6 always comes back flagged as high on bloods. Coffee, alcohol, red meat, and certain vegetables are high in sulfur. Yasko, a homozygous mutation of BHMT 01, BHMT 02, BHMT 04, can produce results similar to one with a CBS upregulation even if you don't have a CBS upregulation. What most people do is go on the elimination diet plus take moly for at least a few weeks. Both the CBS homozygous and heterozygous mutations also have a higher risk for ammonia detoxification issues. https://ibb. An additional benefit of supporting this gene is that it improves methylation. Yasko considers addressing CBS mutations as first priority aside from addressing the gut. 22) that in humans is encoded by the CBS gene. Members Online Can someone please explain this to me - feeling anxious This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. I am in a few CBS Gene Mutation groups online. Both of these mutations talk about excess ammonia build up which can account for some of my central nervous system symptoms. " Okay, I can suggest something that might be of use if you can have someone help you, and you trust their ability to do math and be accurate. Below 6-7 is not good at all. After a few weeks of zinc (only 15 mg) I started feeling cold and fatigued. I will comment later if I can, but that is the most important thing that popped up for me. I have been taking Avmacol sulforaphane (regular dose, 1 tablet instead of the 2 recommended) for the past month for ASD, and honestly I've been all right. 15K subscribers in the MTHFR community. I had a gene mutation report done through Nutrahacker in 2018 and CBS variants didn't appear on the report for me. What is your homocysteine level? It is pretty critical as methylated vitamins are contra indicated for your CBS gene mutation. Amy Yasko's clinical experience and research. Wow I love Reddit so much. The sulfites will build up to toxic levels in your body and cause side effects. It's also supposed to help with COMT mutations and neurotransmitter balance Reply reply Methylated vitamins and methyl donors drive down homocysteine. Members Online FlyingDutchMannen These symptoms include depression, anxiety, brain fog and/or an exacerbating of preexisting conditions. What can I replace those with? High Copper from CBS Mutations. B6 is itself a cofactor for CBS—i. You should take what you test low in. Members Online Is creatine ok for slow COMT and homo c677t? I take L-Ornithine daily because I have some symptoms of high ammonia, possibly from Lyme disease and my CBS polymorphisms. I don’t have mcas per se, but molybdenum has helped dramatically for my histamine intolerance symptoms. That said, I can’t speak to having low bdnf. There's also a link between genetic connective disorders such as EDS and autism. I ran into a problem where I had something akin to an allergic reaction to sulfur. Members Online Got raw data from 23andme. Also +/- MTHFR. SHMT I do not have that so I do not know. Dr. Gene variants are not a diagnosis. Members Online Still Trying to Increase "Too Low" Homocysteine. Or at least, the symptoms don't manifest IN the gut itself. Members Online Mindless_Issy When starting to take Vitamin B12 and L-Methylfolate you might open up detox pathways via the Cystathionine Beta Synthase [CBS] enzyme that have not been opened for a long time, in which case you may feel unwanted symptoms such as mental dullness, feeling spacey and might experience worsening of brain fog. If possible, I would get genetic testing from a hospital for something that sensitive. ) by 3-4 times. If you supplement do not use methylated vitamins. The fibroblast CBS activity may, however, be normal in mild forms of the disease, despite biochemical and clinical abnormalities and mutations in the CBS gene. There are also sulfite free and sulfur free groups on FB and Instagram. I'm thinking that suggests CBS downregulation because B6 is a cofactor of sulphur and those with upregulated would have low B6 since it's burning through it so quickly. One possible consequence of a CBS upregulation is high copper levels. COMT gene mutations limits the body's ability to remove catechols (a specific type of molecule that includes dopamine, norepinephrine, estrogen, etc. I react to methylated b vitamins and stumbled across CBS. So last year I became very ill right after my wedding. On page 2 of what you posted it shows that you are +/- for the CBS T833C gene variant. You could also have GAD65 antibodies blocking the enzyme (any T1D in the family?) Or a functional B6 deficiency. She has mutations of, BHMT-04 :: CT (C/C) - Lower quantity of Methyl groups and lowered metabolism of Homocysteine CBS A360A :: AA (C/C) - Increased CBS activity, so depletes SAM-E Sep 28, 2024 · ANSWER TO 2– CBS mutations are in part to blame for such reactions. The information says to take high doses L-Ornithine. Also if one has slow COMT you might not tolerate supplements which are methyl donors, which NAC is. It's to help with glutathione synthesis, which CBS upregulation reduces (from NutraHacker, SelfDecode). Considering you've got the COMT mutation, if you do decide to give SAMe a try, like anything else, start with small doses. Maybe. I'm wondering what my CBS genes will actually cause, like what symptoms I might have that I can attribute them, and what I can do about them. Do you have any blood work for homocysteine, folate and other vitamins and minerals to share? Need values and lab ranges. Diet links are in my notes in the post. These are my notes on CBS. There is a correlation to the CBS gene mutation. CBS 'CBS' is short for 'cystathionine-beta-synthase'. I would not recommend carnivore with your CBS mutation which I also have. CBS requires B6 to attach to it in order to function properly. And a lot of us with autism have CYP mutations as well and VDR, CBS, PEMT, SOD. With slow COMT and +/+ especially it is best to avoid methylated vitamins. I thought I’d tracked it to CBS, since I’ve always had odd sensitivity to some high sulfur foods and fumes (many cleaning agents make me feel sick). It is the most serious of the CBS genes. I would avoid them. Blood tests, when available, and symptoms determine if a predisposition has been triggered or turned on and is expressing. In my research I came across a lot of conflicting evidence re: the CBS mutation, with the majority calling it "controversial" especially re: ammonia detox and coming down on the side of "there's no good evidence here, but maybe take some B6. In laypersons terms, how important are these and how much of a part could they be playing in my current multiple chronic illnesses? I have slow COMT, mthfr c677t (homogeneous) and the CBS gene mutation. This mutation can also indirectly affect an enzyme called G6PDH, which has negative effects on blood sugar metabolism, red blood cell formation, and blood vessel stability, leading to easy bruising, bleeding, and broken blood vessels AHCY, aka adenosylhomocysteine hydrolase, converts SAH into homocysteine (and adenosine). This means the enzyme works too fast. Then start adding back in small amounts of sulphuric foods to see how much you can tolerate. In that article I discussed how there appears to be two differing perspectives on the nature of CBS (cystathionine beta synthase) gene mutations: the literature’s contention of “down-regulated” CBS enzyme activity among carriers of certain mutations, and certain empirical, clinical observations of the opposite situation, specifically that This intake was enough for my body to develop scary neurological symptoms that I thought was a result of my long COVID. Found out that with CBS gene mutation it is recommended to consume low-sulfur diet. That is very much individual. These can lead to serious health problems, including issues with: Blood – iron deficiency anemia; Liver impairment – Wilson’s disease; Immune system – prolonged viral and fungal infections, delayed wound healing The article is excellent and applies to all of the CBS gene mutations. Gene mutations implicated in excess ammonia are CBS 699T, CBS A360A and MTHFR A1298C. Members Online progesterone mao a serotonin excess Jan 1, 2012 · I have been slowly working through my two known defects, the CBS & the MTHFR A1298C, and have come across some controversy with the CBS C699T enzyme, at least with how Amy Yasko has explained it. Thankfully I identified the problem within a few weeks and went back to normal relatively fast. Dec 10, 2014 · According to Nutrigenomic expert Dr Amy Yasko, the CBS gene mutation must be supported before addressing other genetic variants. Gene & Variation rsID Alleles Result ACAT1-02 rs3741049 GG -/- BHMT-0… Jun 20, 2013 · Yasko mentions those with CBS mutations have an "open door" draining methylation toward transulfuration. Members Online Electrical-Cut573 Aug 28, 2013 · I got my 23andMe results and I have CBS C699T and CBS A360A mutation. Members Online AdministrativeDog721 Methylated vitamins and supplements which are methyl donors are contra indicated for the CBS gene mutation, if it is expressing in you. CBS C699T A GA. They may not be that effective for you and may even be contributing to your symptoms. Did you get your 23andme results back yet? This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Methylated vitamins, activated vitamins and B6 in particular will trigger CBS symptoms. Stop taking the NAC and sulforane. Note that each person is different and can react to supplements differently. COMT mutations first and foremost, MAO-A mutations second. From Genetic Genie; I uploaded raw files from both 23andMe and Ancestry. I suffer from anxiety, OCD, panic attacks, and various other symptoms listed in the article. It appears that gluthatione (as it is a simple sulfur compound) and DIM (as it is made from cruciferous vegetables that are a primary source of sulfur) don't fit. (If context helps: I have confirmed slow COMT and I also suspect BHMT or CBS mutations that 23&me didn't sequence for whatever reason. Google low homocysteine symptoms. Members Online Creatine supplementation - Start up side effects? Since then, I started supplementing D3 and corrected my levels from 17ng/ml to 45ng/ml (stopped getting sick, better sleep and less apathy) but I see I have other weird mutations like MTHFR A1298C homozygous and CBS C699T homozygous. co/x3sybDF. The CBS enzyme can be down regulated (slow) or upregulated (fast). ) B9+B12+copper help recycle homocysteine back to SAM-e via MTR(R). CBS mutations are correlated with digestive issues, so you may want to experiment with pre/pro biotics. In one study, three of 13 CBS deficient patients had normal CBS activity in fibroblasts (Mendes et al 2013). mir181a1hg grn umod g6pd dpyd mtr mtrr actn3 ccdc170 apoe acadvl hps5 cpn1 cbr3 rpgrip1 abcc6 ugt1a1 cbs f5 pex13 itk This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Members Online Can't sleep properly since the first dose of folinic acid. This is not from the group but from my research the CBS problem effects about 20% of the people with mental health problems. Glycine intolerant, Sulfur issues TBD, high serum glycine, can't fuck with methyls) In particular I had severe regression of symptoms from Zinc and Biotin supplementation. Members Online High Homocysteine, High B6, Folate & B12 fine - Lab Results in post CBS Mutations CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. Can even do this with an allergist as the person helping you do a sulfite challenge if you are worried about reaction strength. The SNP rs234706 or C699T in the CBS gene is perhaps the most widely investigated CBS SNP, and also the most controversial. Molybdenum is helpful as well as bismuth. Methylated vitamins and methyl donors drive down homocysteine. I have a homozygous MTRR A66G mutation and apparently am unable to recycle b12 back to its active form (if I'm understanding this correctly). Fast CBS Enzyme = excess taurine and ammonia. I don't eat potatoes often, but had some this week as part of a pre-colonoscopy low-residue diet. This is the main (only?) exit route for homocysteine. You can post with any health issues you are having and I'm sure you'll get some helpful comments! This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. If you ever feel that you have symptoms from taking too much methyl, it’s usually just your homocysteine being at 0. It’s my girlfriend’s results and she has a lot of symptoms and has been not doing well for a few years now after some trauma that I think turned these SNP on in her body. Just Google low homocysteine symptoms to see what they are. 2. . Hey, thanks for the reply. The human CBS gene is located at chromosome 21q22. I do some standard supplements like Vit D, methyl folate and methyl b12. Cystathionine-β-synthase, also known as CBS, is an enzyme (EC 4. I honestly would stop the methylated vitamins and any supplements which are methyl donors. Even with the comt mutations, there were times I could take 300mcg methylcobalamin and 600mcg methyfolate and tolerate it fine. If you find a protocol online for thes This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. CBS You have a sulfite intolerance. My blood results confirmed that my B6 levels were sitting at 244 nmol/l, more than double the normal range of 35 - 110 nmol/l according to my GP. 11 votes, 28 comments. MCAS is NOT a side effect of poor methylation. So how high is high. I definitely have slow COMT just by reading fast vs slow. Genetics Home Ref 26(F), anxiety/panic/PMSSeeking Nutrahacker Advice - Reddit true Thank you so much for your response. BH4 relies on raw material from the folate pathway and recycling of BH4 also relies on DHFR in the folate pathway. Each person has what I call a sulfur bucket or how much they can tolerate. I have reduced my intake of supplements and medication containing sulfur. Before starting you should know that the gene variants are genetic predispositions only. I've seen mention on Ben Lynch's site and elsewhere that the CBS mutation has to be dealt with before the MTHFR, but I haven't yet seen a description of how to go about that. My plan for now is to try to increase dopamine with vitamin D, resveratrol, and zinc. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR… This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Just know that not everyone who follows an elimination diet and is on social media is aware of or have been tested for the CBS gene variant. It is common to see elevated glycine in someone with a homozygous BHMT 08 mutation CBS (CBS C699T, GG, -/-) this is labeled as normal but above in red can explain why I have a sulfur intolerance. 3, and more than 200 disease-causing mutations have been identified . That is because of your reaction and your unknown COMT and CBS status. The only way to know for sure if you are over or undermethylated is to get a histamine blood test. With the CBS gene mutation you may be unable to metabolize them or metabolism may be impaired. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro…. Those are making your symptoms worse. Great FB group CBS Gene Mutation to join and read the files. It was a pretty substantial missing piece for me. 13 votes, 36 comments. Polymorphisms: https://ibb. Author: Michael McEvoy It is important to address that the information regarding CBS pathway activity is still very new, and not everything is well known or understood with regards to what is actually taking place in individuals with said gene mutations, biochemically speaking. If you have MTHFR or CBS mutations that increases homocysteine levels in your tissues, high homocysteine will block the GAD enzyme. We need it be slightly above 0, so we need to eat more meat, eggs and cheese while supplementing. (If you develop different symptoms from this, it might be sulfite toxicity, which then needs molybdenum for SUOX. Many people with CBS also seem to develop MCAS if they do not change their diet. It also recommends Yucca root. Chronic fatigue syndrome and ME or Myalgic Encephalomyelitis also seem to be potential consequences of not making diet changes. Your homocysteine level is close to perfect and I would not recommend you take them. People with specific MTHFR mutations (A1298C and C667T) cannot efficiently metabolize synthetic folic acid, which can cause a number of health problems. Your reaction would seem to validate getting your non MTHFR mutations tested. B6 can help it go down the transulfuration pathway via the enzyme CBS; you might have mutation that makes it slow. But what I said above, to summarize, opportunistic bacterial infections such as strep, staph, C Diff, H. Recommended multivitamin for homozygous CBS C699T mutation? I have a pretty limited diet but understand that methylfolate, methylcobalamine, b6, and other micronutrients can be harmful for someone with this mutation. recently discovered I'm homozygous MTHFR and also homozygous CBS (plus a couple of others). Posted by u/Neurolicker - 3 votes and 7 comments In addition, CBS requires SAM, the main methyl donor output from methylation, for one of its reactions, so improving methylation will also help CBS in this manner. A1298c and the MAO-A mutation can lead to mood swings and higher irritability so I try to be conscious of that in my life. It catalyzes the first step of the transsulfuration pathway , from homocysteine to cystathionine : [ 5 ] The MTHFR gene is responsible for the methylation process inside our bodies. Members Online bonusminutes It does however share symptoms with your homocysteine being 0. I have noticed my symptoms reduce significantly since implementing some of this stuff. Individuals with a CBS mutation (elevated activity) often have high levels of taurine and ammonia and low cystathione and homocysteine (2,3). There is a good FB group CBS Gene Mutation which you could join. Members Online apikalia85 9. There are several SNPs involved. It might also make you feel that way if you have slow or +/+ COMT. So perhaps the liver function benefits from the SAM-E could help this. There were signs in the previous year that I was developing intolerances, like bloating after eating Chipotle or drinking a beer, weird light-headedness every once and a while, not sweating when running, but feeling like I was going to pass out, and being hung over after drinking for multiple days, but they were minor so I didn't think This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Members Online Supplementing Beef Organs for MTHFR? Look into thiamine if you have issues with Magnesium ramping you up. Low or no sulfur sulfates and sulfites diet plus a few supplements. Look for the files to read there. Members Online Suspicious-Turtle-84 This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Ketotifen also contains sulfur. See full list on mygenefood. I have previously had issues taking methyl donors and dont want to risk having another issue taking methylcobalamin since the anxiety is just unreal. com What are CBS gene mutations and what happens if you have a CBS gene mutation? See symptoms for CBS & get tested for CBS gene mutations here Genetic variations in the CBS gene can lead to dysregulation of these pathways and result in elevated homocysteine levels, a condition known as hyperhomocysteinemia. What will be needed to supplement or diet wise with these mutations. Who would imagine that even high quality, organic, Liposomal Vitamin C (as well as the other quality liposomal nutrients that are now available such as Liposomal Magnesium) could cause negative effects due to them being made with Choline. Members Online trippja1 Many people with gut infections or leaky gut have zero obvious symptoms. From what I've read, I need to address this before I start methylation. Researchers have not determined how excess homocysteine leads to the signs and symptoms of homocystinuria. Members Online Can someone please explain this to me - feeling anxious The Information on this enzyme related to methylation is mostly based on Dr. I also seem to have a problem with CBS since I'm sensitive to sulfur foods. Members Online SpiderPlant1 13K subscribers in the MTHFR community. Members Online Genova Methylation Test Results, I was taking Pure Encapsulations Methyl Assist and a methyl b12 chewable tablet at the time of this test. You have the CBS gene. 2K subscribers in the MTHFR community. just switched me to Dr Amy Myers Methylation a list of your symptoms and or diagnoses. I asked my doc for bloodwork on ammonia, taurine, glutamate and cysteine so I could get a read on what my CBS is doing. Skip to main content The CBS is new to me, I've read a lot about MTHFR and some on COMT but the CBS one I've seen so much conflicting info saying it has to be addressed first and cutting out sulfur rich foods. The health reports on 23andMe and Ancestry are very, very limited because it's sourced from saliva. So not MTHFR mutations but definitely others. Time, further research and empirical observations are needed in order to I have symptoms of very low dopamine (sluggish, fatigued, zero motivation) and I have low vitamin D, even though I spend a lot of time in the sun and live in the southern US. Pylori or even pathogens like candida or parasites will take the upper hand over your nutritional stores for survival. The cofactors are B6, heme iron, serine. CBS trumps all your others. COMT and CBS should be prioritized over your genes insofar as supplement instructions. This "slow" variat This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. it’s so rare that something works this dramatically, but based on my CBS gene mutation my doc said I probably needed it to help process all the histamine that was building up. I can’t believe SDT and Cognitive Disengagement Syndrome, I haven’t heard of these, and the quickest google search I’m like omg, there’s a name for what I’m feeling, I could cry. This is due to the rapid conversion and if this is coupled with NOS You have the most serious of the two primary CBS mutations. Members Online Am I a candidate for MTFHR/COMT testing according to these symptoms? 12 votes, 42 comments. CBS C19150T A GA. This condition is associated with various health issues, including vascular diseases, neurological disorders, and congenital flaws. As per gene databases, the SNPs at positions 1 & 19 of the structural domain will have pretty insignificant impact on enzyme function and aren't implicated in any diseases. COMT is the main determinant of whether or not methyls and methyl donors would work for you. Turns out that the BHMT gene also has something to do with sulfur regulation; the symptoms mimic CBS. CBS is an enzyme which uses some homocysteine from the methionine cycle to another set of pathways (transsulfuration pathway), which include the creation of the important antioxidant glutathione. Due to the high levels of taurine and ammonia this mutation causes, it is common to see lower levels of cystathionine and homocysteine. FB has a great group CBS Gene Mutation which I am in. That open door also requires B6 (or P5P/PLP depending on which diagram you look at). Get all your gene variant tested and not just MThFR. Wondering if people that are CBS+, especially if they have good methylation or taking SMP supps, might be prone to B6 deficiency? Just passing on whats helped me: off the top of my head your mutations makes it likely you'll benefit from Vit D3, Methylfolate, active B12 - get your levels checked if you have the money/time otherwise start supplementing and see if you can feel a noticeable difference. I take Vyvanse 50 mg and it completely eliminates my anxiety and evens out my mood. CBS defects are actually upregulations. MCAS symptoms are very much the result of your CBS gene variant. I am hoping NH is incorrect as I was pleased to have no BHMT or CBS mutations after the overwhelming job of trying to understand all my other mutations. Jun 23, 2019 · These mutations disrupt the normal function of cystathionine beta-synthase. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. I would post this on r/MTHFR as you can get a lot more insights into your mutations. So it can affect you even if you are not +/+. 🙏🙏 Thanks again This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. I’ve also struggled with anxiety my whole life. Your body has a hard time breaking down sulfites in foods, drinks, supplements and pharma drugs. Members Online Why would creatine give someone insomnia even at low doses? The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. ybtg vffm adqc tkakkia dzngn tljcaei vyhlo ikfalv fzlqjy ofs